Premature ovarian failure - Vibrant Life

Premature Ovarian Failure (POF)

Premature ovarian failure (POF), also known as primary ovarian insufficiency, is when a woman's ovaries stop functioning normally before age 40. The ovaries make fewer eggs, and hormones like estrogen and progesterone decline.

POF happens because a woman's egg supply in her ovaries declines faster than normal for her age. Doctors don't always know the exact cause. Known causes include:

• Genetic factors like Turner syndrome and Fragile X syndrome
• Autoimmune diseases
• Cancer treatments like chemotherapy or radiation
• Infections like mumps
• Metabolic disorders like galactosemia

The key signs of POF include:

• Irregular or missed periods before age 40
• Hot flashes, night sweats, vaginal dryness (menopause-like symptoms)
• Difficulty getting pregnant

To diagnose POF, doctors will check follicle stimulating hormone (FSH) and estradiol blood levels. They may examine your ovaries with an ultrasound.

Some cases of POF are reversible, so seeing an endocrinologist to explore treatment options is important. Options may include:

• Hormone therapy with estrogen/progesterone to relieve menopause symptoms
• Fertility drugs or procedures like IVF to aid pregnancy
• Lifestyle changes like stress reduction

The outlook for women with POF varies. Some regain normal cycles periodically. Some can get pregnant and deliver healthy babies, especially with fertility treatment.

Early menopause symptoms can significantly impact one's quality of life. Connecting with support groups can help women cope with the psychological effects. Though challenging, many women go on to live full, productive lives.